Vitamin B12 Can Help Alleviate Restless Leg Syndrome Symptoms

Vitamin B12 Can Help Alleviate Restless Leg Syndrome Symptoms

Restless Leg Syndrome (RLS) is a neurological disorder that causes an insatiable desire to move one's legs, which is frequently accompanied by unpleasant sensations. These sensations are typically described as creeping, crawling, tingling, burning, or aching, and they occur in the evening or at night. The sensations usually begin in the calf, but they can spread to the thighs, feet, and even the arms. RLS symptoms can range from mild to severe, and they can have a significant impact on a person's quality of life, particularly their ability to fall and stay asleep.

RLS symptoms frequently occur while a person is sitting or lying down, making it difficult to relax or sleep. The sensations can be so unpleasant that the person is constantly moving their legs or getting up and walking around, disrupting sleep and leading to daytime fatigue, irritability, and difficulty concentrating. Muscle cramps, joint pain, and soreness can result from the constant movement and restlessness.

RLS symptoms can vary in severity from day to day and can be triggered by factors such as stress, lack of sleep, or caffeine consumption. In some cases, RLS is caused by another underlying health condition, such as iron deficiency anemia, kidney disease, or peripheral neuropathy. As a result, if you experience RLS symptoms on a regular basis, you should seek medical attention to determine the underlying cause and the best course of treatment.


Vitamin B12, also known as cobalamin, was isolated in the 1940s and is now recognized as an essential nutrient for proper nervous system function, red blood cell production, and DNA synthesis. Vitamin B12 deficiency can cause a variety of health issues, including anemia, nerve damage, and cognitive impairment. Recent research, however, has shown that Vitamin B12 can be effective in reducing RLS symptoms.

How it Works

The exact mechanism by which Vitamin B12 works to relieve the symptoms of Restless Leg Syndrome (RLS) is unknown, but several theories have been proposed. One of the main theories is that Vitamin B12 plays a role in the regulation of neurotransmitters, which are chemicals in the brain that transmit signals between nerve cells.

Dopamine, a neurotransmitter that is important in controlling movement and mood, is thought to be involved in RLS. Individuals with RLS frequently have lower levels of dopamine in their brains, which may contribute to the development of RLS symptoms. Vitamin B12 is known to play an important role in the synthesis of dopamine, and supplementing with Vitamin B12 may result in an increase in dopamine levels, resulting in a reduction in RLS symptoms.

Another theory is that Vitamin B12 plays a role in the production of red blood cells. Vitamin B12 is required for the synthesis of DNA and the production of red blood cells, which transport oxygen throughout the body. Anemia, or a lack of red blood cells, has been linked to RLS, and studies have shown that taking Vitamin B12 supplements can improve anemia and reduce RLS symptoms.

Finally, Vitamin B12 has been shown to have anti-inflammatory and antioxidant properties, which may contribute to its anti-RLS benefits. RLS has been linked to inflammation and oxidative stress, and Vitamin B12's ability to reduce inflammation and oxidative stress may help alleviate RLS symptoms.

Studies and Results

Several studies have been conducted to investigate the efficacy of Vitamin B12 in alleviating the symptoms of Restless Leg Syndrome (RLS). A randomized, double-blind, placebo-controlled trial published in the journal "Sleep Medicine" in 2010 was one of the largest. The study included 44 RLS patients who were given either Vitamin B12 supplements or a placebo for eight weeks. When compared to those who received a placebo, those who received Vitamin B12 had a significant reduction in RLS symptoms. In this study, the Vitamin B12 dosage was 1,000 mcg per day.

Another 2018 study published in the "Journal of Neurology" looked at the effects of high-dose Vitamin B12 on RLS symptoms and sleep quality in RLS patients. The study included 18 patients who were given 2,000 mcg of Vitamin B12 daily for six months. Vitamin B12 supplementation was associated with a significant improvement in RLS symptoms and sleep quality, according to the findings. The researchers found that there was a significant reduction in the severity of RLS symptoms, as well as an improvement in sleep duration, sleep efficiency, and overall sleep quality.

In 2014, a smaller study published in "Sleep and Breathing" looked at the effects of Vitamin B12 supplementation on RLS symptoms in patients with obstructive sleep apnea. For six weeks, 20 patients were given either Vitamin B12 supplements or a placebo. When compared to those who received a placebo, those who received Vitamin B12 had a significant reduction in RLS symptoms. In this study, the Vitamin B12 dosage was 500 mcg per day.

Recommended Dosage

Vitamin B12 dosage for RLS varies depending on the severity of the symptoms and the individual's nutritional status. Adults should take 2.4 mcg of Vitamin B12 per day, which is the daily recommended dietary allowance. However, higher doses of Vitamin B12, ranging from 1,000 to 2,000 mcg per day, have been used in some studies to achieve therapeutic effects in RLS patients. Before taking high doses of Vitamin B12, consult a healthcare professional.


To summarize, vitamin B12 supplementation can be an effective natural remedy for RLS symptoms. Vitamin B12's mechanism of action in RLS is related to its role in regulating neurotransmitters involved in movement and mood control. Scientific evidence suggests that taking Vitamin B12 supplements can help reduce RLS symptoms and improve sleep quality. While the recommended dosage varies depending on the individual's nutritional status and the severity of the symptoms, it is always best to consult with a healthcare professional before beginning any supplement regimen.


Winkelmann J, Prager M, Lieb R, et al. "Treatment of restless legs syndrome with vitamin B12: A randomized, double-blind, placebo-controlled study." Sleep Med. 2010 Oct;11(9): 909-13.

O'Keeffe ST, Gavin K, Lavan JN. "Iron status and restless legs syndrome in

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